Advances in solution- and solid-phase synthesis toward the generation of natural product-like libraries.
نویسندگان
چکیده
4.1. Aeruginosin 298-A 2002 4.2. Bleomycin 2003 4.3. Clavulones 2004 4.4. Curacin A 2005 4.5. Dysidiolide 2006 4.6. Epothilone 2006 4.7. Erythromycin A 2007 4.8. Estrone 2008 4.9. Fellutamide 2009 4.10. Fumiquinazoline 2010 4.11. Gougerotin 2010 4.12. Homocamptothecin 2010 4.13. Illudin 2011 4.14. Macrosphelide 2012 4.15. Mappicine 2012 4.16. Mniopetals and Marasmanes 2013 4.17. Murisolin 2014 4.18. Passifloricin 2016 4.19. Naltrindole 2017 4.20. Nakijiquinone 2017 4.21. (+)-Plicamine 2018 4.22. Saframycin 2018 4.23. Stylostatin 2018 4.24. Ursolic Acid 2019 4.25. Vitamin D3 2020 5. Solid-Phase Synthesis of Cyclic Peptides as Natural Products and Analogs 2020
منابع مشابه
Part 2: building diverse natural-product-like architectures from a tetrahydroaminoquinoline scaffold. Modular solution- and solid-phase approaches for use in high-throughput generation of chemical probes.
The solution- and solid-phase synthesis to obtain several natural-product-like, tetrahydroquinoline-based, polycyclic derivatives were developed. In one approach, two derivatives (38 and 41) having an eight-membered unsaturated lactam were successfully obtained both in solution and on solid support.
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Comparing a solution phase route to a solid phase route in the synthesis of the cytotoxic natural product urukthapelstatin A (Ustat A) confirmed that a solid phase method is superior. The solution phase approach was tedious and involved cyclization of a ridged heterocyclic precursor, while solid phase allowed the rapid generation of a flexible linear peptide. Cyclization of the linear peptide w...
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A diversity-oriented solution and solid-phase synthesis of tetrahydroquinoline-based tricyclic derivatives has been achieved from enantiomerically pure, natural product-like bicyclic scaffold. The solution synthesis of enantiopure bicyclic scaffold was developed by asymmetric hetero Michael reaction. Our approach for the synthesis of polycyclic derivatives utilized regio- and stereoselective he...
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عنوان ژورنال:
- Chemical reviews
دوره 109 5 شماره
صفحات -
تاریخ انتشار 2009